Transduksi Sinyal Hormon Kolesistokinin sebagai Target untuk Mengatasi Obesitas

Hidayat, Meilinah and Sujatno, Muchtan and N., Nugraha and S., Setiawan (2010) Transduksi Sinyal Hormon Kolesistokinin sebagai Target untuk Mengatasi Obesitas. Jurnal Kedokteran Maranatha, 9 (2). pp. 1-10. ISSN 1411-9641

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Abstract

In the last decade, the number of overweight children and adults has increased all over the world. In Indonesia, obesity needs serious management because it is multi-factorial etiology. One of the predominant factors of obesity is excessive-appetite. This paper aims to discuss a gut hormone called cholecystokinin (CCK), which has been proven to be able to decrease appetite. CCK has a short term anorectic effect, which becomes the reason for the hormone to be one of therapeutic targets of obesity in the future. CCK is produced in the enteroendocrine cell along the small gut mucous and the secretion is stimulated by protein and fat through signal transduction mechanisms called G Protein Coupling Receptor (GPCR), GPR 93. Then they activate Extracellular Signal-Related Kinase (ERK) 1/2 through Gαq and Gαi signal transduction. Soybean contains a bioactive protein, β-conglycinin (BconP) subunit–β, which has been proven to be the best inducer for CCK secretion. The well-known signal transduction pathway is Gαq-coupled GPCR, which influences the calcium signal and activates Protein Kinase C (PKC). However, the downstream signaling to complete the pathway remains unclear and further study will be needed to explore the whole process.

Item Type:	Article
Uncontrolled Keywords:	signal transduction, cholecystokinin, fat, protein, β-conglycinin
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Fakultas Kedokteran
Depositing User:	admin LPPM
Date Deposited:	08 Aug 2017 02:44
Last Modified:	14 Aug 2017 03:11
URI:	http://repository.lppm.maranatha.edu/id/eprint/54

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