Ekstrak Kedelai Detam 1, Daun Jati Belanda Serta Kombinasinya Terhadap Berat Badan dan Histopatologis Hepar Tikus Wistar

Hidayat, Meilinah and Soeng, Sylvia and Wahyudianingsih, Roro and Ladi, Jeanny Ervie and Krisetya, Yonathan Ari and Elviora, Vera (2015) Ekstrak Kedelai Detam 1, Daun Jati Belanda Serta Kombinasinya Terhadap Berat Badan dan Histopatologis Hepar Tikus Wistar. Jurnal Kedokteran dan Kesehatan Indonesia, 6 (4). pp. 1-12. ISSN p-ISSN 2085-4145 & e-ISSN 2527-2950

Text 4. Meilinah H.,Sylvia Soeng,Roro W.,Jeanny, Yonathan&Vera.pdf - Published Version Restricted to Registered users only Download (280kB)

Abstract

Background Detam 1 soybeans and Jati Belanda leaves have inhibitory weight gain effects. In the purpose to inhibit weight gain, it can harm the liver organ. Objective This study was carried-out to find the effects of ethanol extract of Detam 1 soybeans and ethanol extract of Jati Belanda leave and their combinations in decreasing body weight and liver's histopathological changes on male Wistar rats induced high-fat feed . Method The method of the research was true laboratory experiments with a comparative Completely Randomized Design (CRD) which used 40 rats. Experimental animals were divided into 8 groups (n=5). The treatments were administered for 28 days. On the 29th day, all rats were sacrificed and their livers were made into histopathology slide using Haematoxylin Eosin (HE) coloring technique. Results All treatments showed inhibitory weight gain effects and the best is administrations of combination of EEDS 10 mg and EEJB 20 mg. All treatments caused liver architecture structure changes and inflammation in portal area but did not caused cloudy swelling and fatty degeneration in male Wistar rats liver, and the EEJB caused the worst. Conclusion Administrations of combination of EEDS 10 mg and EEJB 20 mg give the best result to prevent weight gain and EEJB caused the worst changes in liver histopathological features.

Item Type:	Article
Uncontrolled Keywords:	Detam 1 soybean, Jati Belanda, weight gain, liver's histopathological, Wistar Rats
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Kedokteran
Depositing User:	admin LPPM
Date Deposited:	08 Aug 2017 02:03
Last Modified:	10 Aug 2017 08:48
URI:	http://repository.lppm.maranatha.edu/id/eprint/43

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