Comparisson of The Effect of Three Exact Sort of Soybean DETAM 1 on The Total Cholesterol Level Balb-C Male Mice

Hidayat, Meilinah and Kiong, Khie and Siswanto, Christina Melissa (2012) Comparisson of The Effect of Three Exact Sort of Soybean DETAM 1 on The Total Cholesterol Level Balb-C Male Mice. The Indonesian Biomedical Journal, 4 (3). pp. 1-10. ISSN Print ISSN: 2085-3297, Online ISSN: 2355-9179

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Abstract

Background:Hypercholesterolemia is a major risk factor for coronary heart disease. Pharmacological treatment of hypercholesterolemia are known to have side effect, hence the need for an alternative medicine, like herbal medicine, such as soybean as an example. Research objective is to compare the effect of ethanol extract, protein extract, and ethyl acetate fraction of soybean tempeh Detam-1 on the total serum cholesterol level of male mice. METHODS:This study was al laboratory experimental study with Completely Randomized Design (CRD) method. Twenty five Balb-C strain male mice were allocated into five groups, namely: the negative-control (aquabidest), the positive-control (simvastatin),ethanol extract, protein extract and ethyl acetate fraction of the soybean tempeh Detam-1 all were fed with high cholesterol containing food for 31 days. Starting on the 18th day all groups were treated for 14 days. The observed parameter was the total serum cholesterol level. The data of the study result were analyzed with ANOVA, followed by Tukey HSD test. RESULT:There were significant differences between treatment groups and the negative-control (p=0,0004). The reduction of the total cholesterol level of soy tehanol extract was 35,11% -+ 15, the ethyl acetate fraction of soybean tempeh 26,47%-+ 17,and soy protein extract was15,33%-+33,1, and no significant difference was noted in the positive-control group (simvastatin). CONCLUSION: The ethanol extract of soybean seed,protein extract of soybean seed, and ethyl acetate fraction of soybean tempeh Detam-1 have the same effect as do simvastatin, and ethanol extract of soybean seed is the msot effective substance for lowering total serum cholesterol in Balb-C male mice.

Item Type:	Article
Uncontrolled Keywords:	Hypercholesterolemia, ethanol extract, protein extract and ethyl acetate fraction, soybean Dteam-1
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Kedokteran
Depositing User:	admin LPPM
Date Deposited:	08 Aug 2017 02:45
Last Modified:	10 Aug 2017 09:03
URI:	http://repository.lppm.maranatha.edu/id/eprint/55

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